Cebro Márquez, MaríaRodríguez Mañero, MoisésSerrano Cruz, ValentinaVilar Sánchez, MartaGonzález Melchor, LailaGarcía Seara, JavierMartínez Sande, José LuisAragón Herrera, AlanaMartínez Monzonís, María AmparoGonzález Juanatey, José RamónLage Fernández, RicardoMoscoso Galán, Isabel2024-02-012024-02-012023Cebro-Márquez, M.; Rodríguez-Mañero, M.; Serrano-Cruz, V.; Vilar-Sánchez, M.E.; González-Melchor, L.; García-Seara, J.; Martínez-Sande, J.L.; Aragón-Herrera, A.; Martínez-Monzonís, M.A.; González-Juanatey, J.R.; et al. Plasma miR-486-5p Expression Is Upregulated in Atrial Fibrillation Patients with Broader Low-Voltage Areas. Int. J. Mol. Sci. 2023, 24, 15248. https://doi.org/10.3390/ijms242015248http://hdl.handle.net/10347/32199Atrial fibrillation (AF) is the most common arrhythmia worldwide, affecting 1% of the population over 60 years old. The incidence and prevalence of AF are increasing globally, representing a relevant health problem, suggesting that more advanced strategies for predicting risk stage are highly needed. miRNAs mediate several processes involved in AF. Our aim was to identify miRNAs with a prognostic value as biomarkers in patients referred for AF ablation and its association with LVA extent, based on low-voltage area (LVA) maps. In this study, we recruited 44 AF patients referred for catheter ablation. We measured the expression of 84 miRNAs in plasma from peripheral blood in 3 different groups based on LVA extent. Expression analysis showed that miR-486-5p was significantly increased in patients with broader LVA (4-fold, p = 0.0002; 5-fold, p = 0.0001). Receiver operating characteristic curve analysis showed that miR-486-5p expression could predict atrium LVA (AUC, 0.8958; p = 0.0015). Also, miR-486-5p plasma levels were associated with AF-type (AUC, 0.7137; p = 0.0453). In addition, miR-486-5p expression was positively correlated with LVA percentage, left atrial (LA) area, and LA volume (r = 0.322, p = 0.037; r = 0.372, p = 0.015; r = 0.319, p = 0.045, respectively). These findings suggest that miR-486-5p expression might have prognostic significance in LVA extent in patients with AFeng© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Atrial fibrillationmicroRNAsLow-voltage areasBiomarkersmiR-486-5pjournal article10.3390/ijms2420152481422-0067open access