Rodríguez Pombo, LucíaMartínez Castro, LauraXu, XiaoyanOng, Jun JieRial, CarlosGarcía, Daniel NietoGonzález Santos, AlejandroFlores González, Julián CarlosÁlvarez Lorenzo, CarmenBasit, Abdul W.Goyanes Goyanes, Álvaro2025-10-212025-10-212023-02-15International Journal of Pharmaceutics: X Volume 5, December 2023, 1001662590-1567https://hdl.handle.net/10347/433193D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry.eng© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Vat photopolymerization 3D printed medicines3D rotary printingTomographic reconstruction3D printed drug productsPrinting pharmaceuticals and drug delivery systemsPersonalized formulationsjournal article10.1016/j.ijpx.2023.100166open access