Louzao Ojeda, María del CarmenVilariño del Río, NataliaVale González, María del CarmenCostas, CeliaCao Cancelas, AlejandroRaposo García, SandraRodríguez Vieytes, MercedesBotana López, Luis Miguel2025-01-142025-01-142022Louzao, M.C.; Vilariño, N.; Vale, C.; Costas, C.; Cao, A.; Raposo-Garcia, S.; Vieytes, M.R.; Botana, L.M. Current Trends and New Challenges in Marine Phycotoxins. Mar. Drugs 2022, 20, 198. https://doi.org/10.3390/ md20030198https://hdl.handle.net/10347/38572Marine phycotoxins are a multiplicity of bioactive compounds which are produced by microalgae and bioaccumulate in the marine food web. Phycotoxins affect the ecosystem, pose a threat to human health, and have important economic effects on aquaculture and tourism worldwide. However, human health and food safety have been the primary concerns when considering the impacts of phycotoxins. Phycotoxins toxicity information, often used to set regulatory limits for these toxins in shellfish, lacks traceability of toxicity values highlighting the need for predefined toxicological criteria. Toxicity data together with adequate detection methods for monitoring procedures are crucial to protect human health. However, despite technological advances, there are still methodological uncertainties and high demand for universal phycotoxin detectors. This review focuses on these topics, including uncertainties of climate change, providing an overview of the current information as well as future perspectives.eng© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licensehttp://creativecommons.org/licenses/by/4.0/PhycotoxinMechanism of actionToxicityTherapeutic applicationDetection methodsjournal article10.3390/ md20030198open access