Couselo Carreira, MarcosAndrade, Sara María Monteiro SousaGonzález Izquierdo, AndreaAmil Diz, MaríaFolgueira Cobos, CintiaCrujeiras Martínez, Ana BelénCasanueva Freijo, Felipe2020-05-062020-05-062018Carreira, M.C., Andrade, S., Gonzalez-Izquierdo, A. et al. Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain. Sci Rep 8, 17155 (2018). https://doi.org/10.1038/s41598-018-34840-7http://hdl.handle.net/10347/22091The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with antiobesity activity. The effects of OBEX have been tested in vivo and in vitro. In vivo, OBEX reduces weight gain by decreasing adiposity gain and increasing energy expenditure in high fat diet-fed mice through the activation of thermogenesis in brown adipose tissue (BAT) independent of eating behaviors. In vitro analysis with 3T3-F442A cells revealed anti-proliferative and anti-differentiation effects of OBEX. In addition, OBEX induced a clear reduction of the lipid load in mature adipocytes obtained from 3T3-F442A cells. Overall, our findings suggest that OBEX has a protective effect against an obesogenic environmenteng© The Author(s) 2018. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/4.0/Endocrine system and metabolic diseasesEndocrinologyObesityjournal article10.1038/s41598-018-34840-72045-2322open access