Abbadessa, AnnaCrecente Campo, JoséAlonso Fernández, María José2020-11-022021-08-2620201937-3368http://hdl.handle.net/10347/23531The authors acknowledge the original source of publication. Final publication is available from Mary Ann Liebert, Inc.: http://dx.doi.org/10.1089/ten.teb.2020.0096Human meniscus is a fibrocartilaginous structure that is crucial for an adequate performance of the human knee joint. Degeneration of the meniscus is often followed by partial or total meniscectomy, which enhances the risk of developing knee osteoarthritis. The lack of a satisfactory treatment for this condition has triggered a major interest in drug delivery (DD) and tissue engineering (TE) strategies intended to restore a bioactive and fully functional meniscal tissue. The aim of this review is to critically discuss the most relevant studies on spatiotemporal DD and TE, aiming for a multizonal meniscal reconstruction. Indeed, the development of meniscal tissue implants should involve a provision for adequate active molecules and scaffold features that take into account the anisotropic ultrastructure of human meniscus. This zonal differentiation is reflected in the meniscus biochemical composition, collagen fiber arrangement, and cell distribution. In this sense, it is expected that a proper combination of advanced DD and zonal TE strategies will play a key role in the future trends in meniscus regenerationengCopyright 2020, Mary Ann Liebert, Inc., publishers.MeniscusDrug deliveryGrowth factorsZonal reconstructionTissue engineeringAnisotropic tissue regenerationjournal article10.1089/ten.teb.2020.00961937-3376open access