Castro Tubío, José ManuelRodríguez Martín, Bernardo2022-06-292022-06-292022http://hdl.handle.net/10347/28860This PhD dissertation provides further insights on the impact of retrotransposon mobilisation in the cancer genome. Through the analysis of a large cohort of 2,954 cancer whole genomes compiled by the Pan-Cancer Analysis of Whole Genomes Consortium, we have investigated the patterns of somatic activity for mobile elements across 38 different tumour types, uncovered novel mechanisms of mutation mediated by LINE-1 elements and characterised more than 100 full-length LINE-1 loci active in cancer.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/RetrotransposonesCancerBiología ComputacionalMaterias::Investigación::24 Ciencias de la vida::2410 Biología humana::241007 Genética humanadoctoral thesisopen access