Martínez-Calvo, MiguelRodríguez Couceiro, JoséDestito, PaoloRodríguez Villar, JéssicaMosquera Mosquera, JesúsMascareñas Cid, José Luis2018-06-212018-06-212018-06-01Martínez-Calvo, M., Couceiro, J., Destito, P., Rodríguez, J., Mosquera, J., & Mascareñas, J. (2018). Intracellular Deprotection Reactions Mediated by Palladium Complexes Equipped with Designed Phosphine Ligands. ACS Catalysis, 6055-6061. doi: 10.1021/acscatal.8b01606http://hdl.handle.net/10347/16860Discrete palladium(II) complexes featuring purposely designed phosphine ligands can promote depropargylation and deallylation reactions in cell lysates. These complexes perform better than other palladium sources, which apparently are rapidly deactivated in such hostile complex media. This good balance between reactivity and stability allows the use of these discrete phosphine palladium complexes in living mammalian cells, whereby they can mediate similar transformations. The presence of a phosphine ligand in the coordination sphere of palladium also provides for the introduction of targeting groups, such as hydrophobic phosphonium moieties, which facilitate the accumulation of the complexes in mitochondriaeng© 2018 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (https://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposesBioorthogonalDiscrete complexesIntracellular catalysisMitochondrial confinementPalladiumjournal article10.1021/acscatal.8b016062155-5435open access