Montoto Pintos, DavidDeus Lorenzo, UxíaTomás Gamasa, MaríaMascareñas Cid, José LuisMato Gómez, Mauro2025-10-162025-10-162025Montoto, D., Deus-Lorenzo, U., Tomás-Gamasa, M., Mascareñas, J. L., Mato, M. (2025). Red-shifted photoredox generation and trapping of alkyl radicals towards bioorthogonality. "Organic & Biomolecular Chemistry"1477-0520https://hdl.handle.net/10347/43125The photocatalytic generation and trapping of alkyl radicals is a powerful synthetic tool in organic chemistry, but it remains underexplored in biological settings. Here, we present two photoredox systems that leverage green- or red-light irradiation for the activation and subsequent Giese coupling of redox-active alkyl phthalimide esters. Besides utilizing mild low-energy light sources, these reactions operate with biocompatible BnNAH or NADH as electron donor. Notably, they display compatibility with air, water and biologically relevant conditions, including cell-culture media or even cell lysates. This work marks a significant step towards integrating synthetic alkyl-radical chemistry into biological settings.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/2306 Química orgánicajournal article10.1039/d5ob00476d1477-0539open access