Estévez Souto, ValentínSilva Álvarez, Sabela daCollado Rodríguez, Manuel2023-06-262023-06-262022The FEBS Journal 290 (2023) 1203–1211. doi:10.1111/febs.165851203–1211http://hdl.handle.net/10347/30798Cellular senescence, an evolutionarily conserved mechanism that prevents the proliferation of damaged cells, is a very relevant cellular response involved in both physiological and pathological conditions. Even though senescent cells are stably growth arrested, they exhibit a complex and poorly understood secretory phenotype, known as senescence-associated secretory phenotype, composed of soluble proteins and extracellular vesicles (EVs). Extracellular vesicles were initially described as a waste management mechanism to remove damaged components of cellular metabolism, but increasing evidence shows that EVs could also play important roles in intercellular communication. Recently, some studies showed that EVs could have fundamental functions during cellular senescence. Our purpose in this review is to clarify the increasing literature on the role of EVs in cellular senescence as key mediators in cell-to-cell communicationeng©2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/Cellular senescenceEVsExtracellular vesiclesIntercellular communicationjournal articleopen access