Rodicio Rodicio, María CelinaBarreiro Iglesias, AntónRomaus-Sanjurjo, Daniel2018-05-072018-05-072018http://hdl.handle.net/10347/16702Spinal cord injury (SCI) causes irreversible loss of function. In contrast to mammals, lampreys show an amazing capacity for spontaneous recovery after a complete SCI. They provide an interesting model to understand the molecular processes that lead to spontaneous recovery. In this study, we analysed the changes in the expression of both gabab subunits after a complete SCI. Our results showed that plastic changes in this system probably contribute to the recovery of function after SCI in lampreys. Pharmacological and genetic manipulations revealed that endogenous GABA acting through GABAB receptors promotes axonal regeneration of descending neurons after a complete SCI in lampreys.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/sea lampreyGABAB receptorspinal cord injuryaxonal regenerationMaterias::Investigación::24 Ciencias de la vida::2401 Biología animal (zoología)::240104 Citología animalMaterias::Investigación::24 Ciencias de la vida::2499 Otras especialidades biologicas (neurorregeneración)doctoral thesisopen access