Otero Espinar, Francisco JavierLema Gesto, María IsabelGonzález Barcia, MiguelVarela Fernández, Rubén2022-08-012022-12-272022http://hdl.handle.net/10347/28967In the present thesis, the research, development, and characterization processes of controlled drug delivery systems intended for the treatment of two different ocular pathologies were described. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administration were developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On the other hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as new therapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/KeratoconusLeber's Hereditary Optic NeuropathyNanoparticlesLactoferrinIntravitreal implantControlled Drug DeliveryTopical Ophthalmic administrationIntravitreal administrationMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320990 Farmacología experimentaldoctoral thesisopen access