Mallo López, Sabela CarmePatten, ScottIsmail, ZahinoorPereiro Rozas, Arturo X.Facal Mayo, DavidOtero Ortega, CarlosJuncos Rabadán, Onésimo2024-02-022024-02-022020References Mallo, S. C., Patten, S. B., Ismail, Z., Pereiro, A. X., Facal, D., Otero, C., & Juncos-Rabadán, O. (2020). Does the neuropsychiatric inventory predict progression from mild cognitive impairment to dementia? A systematic review and meta-analysis. Ageing Research Reviews, 58, 1010041568-1637http://hdl.handle.net/10347/32252Background Neuropsychiatric Symptoms (NPS) are common in Mild Cognitive Impairment (MCI). The Neuropsychiatric Inventory (NPI) and its shorter version, the Neuropsychiatric Inventory Questionnaire (NPI-Q), are the most common measures to assess NPS. Our objective was to determine if NPI/NPI-Q ratings predict conversion from MCI to dementia. Methods Empirical longitudinal studies published in English or Spanish, concerned with the role of NPS as a risk factor for conversion from MCI to dementia, with a diagnosis of MCI following clinical criteria, that reported NPI/NPI-Q total score in converters versus non-converters, were included. Random effects models were used, and heterogeneity was explored with stratification and a random-effects meta-regression. The overall conversion rate and the standardized mean difference (SMD) for evolution, as a function of NPI/NPI-Q scores, were calculated. Results The overall conversion rate was 35 %. Mean NPI/NPI-Q ratings were higher in converters versus in non-converters, with the overall SMD approaching significance. Heterogeneity was observed in studies of more than two years of follow-up and in a study with a mean age of more than 80 years. This heterogeneity concerned the size, not the direction of the difference. Conclusions Our results suggest that NPI/NPI-Q ratings are associated with conversion from MCI to dementiaengCC-BY-NC-NDNeuropsychiatric symptomsMild cognitive impairmentDementiaNeuropsychiatric inventoryNeuropsychiatric inventory questionnaireMeta-analysisDoes the neuropsychiatric inventory predict progression from mild cognitive impairment to dementia? A systematic review and meta-analysisjournal article10.1016/j.arr.2019.1010041872-9649open access