Gulías Costa, MoisésMascareñas Cid, José Luis2016-09-082017-08-292016-06-22M. Gulías, J. L. Mascareñas, Angew. Chem. Int. Ed. 2016, 55, 11000E-ISSN 1521-3773http://hdl.handle.net/10347/14870NOTICE: This is the peer reviewed version of the following article: Moisés Gulías* and José L. Mascareñas* (2016), Metal-Catalyzed Annulations through Activation and Cleavage of C-H Bonds. Angew. Chem. Int. Ed., 55, 11000-11019 [doi:10.1002/anie.201511567 (International Edition), 10.1002/ange.201511567 (German Edition)]. This article may be used for noncommercial purposes in accordance with Wiley Terms and Conditions for self-archivingThe exponential increase in the number of catalytic transformations that involve a metal-promoted activation of hitherto considered inert C−H bonds is promoting a fundamental change in the field of synthetic chemistry. Although most reactions involving C−H activations consist of simple functionalizations or additions, recent years have witnessed an upsurge in related transformations that can be formally considered as cycloaddition processes. These transformations are particularly appealing from a synthetic perspective because they allow the conversion of readily available substrates into highly valuable cyclic products in a rapid and sustainable manner. In many cases, these annulations involve the formation of metallacyclic intermediates that resemble those proposed for standard metal-catalyzed cycloadditions of unsaturated precursorseng© WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimC−H activationCycloadditionHeterocyclesHomogeneous catalysisTransition metalsMaterias::Investigación::23 Química::2302 Bioquímicajournal article10.1002/anie.201511567open access