Matos, Maria João Correia Pinto Carvalho deVázquez Rodríguez, SaletaSantana Penín, María LourdesUriarte Villares, EugenioFuentes Edfuf, CristinaSantos Rodríguez, YsabelMuñoz Crego, Ángeles2020-06-192020-06-192013Matos, M.J.; Vazquez-Rodriguez, S.; Santana, L.; Uriarte, E.; Fuentes-Edfuf, C.; Santos, Y.; Muñoz-Crego, A. Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents. Molecules 2013, 18, 1394-1404http://hdl.handle.net/10347/23045A new series of amino/nitro-substituted 3-arylcoumarins were synthesized and their antibacterial activity against clinical isolates of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was evaluated. Some of these molecules exhibited antibacterial activity against S. aureus comparable to the standards used (oxolinic acid and ampicillin). The preliminary structure-activity relationship (SAR) study showed that the antibacterial activity against S. aureus depends on the position of the 3-arylcoumarin substitution pattern. With the aim of finding the structural features for the antibacterial activity and selectivity, in the present manuscript different positions of nitro, methyl, methoxy, amino and bromo substituents on the 3-arylcoumarin scaffold were reportedeng© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)http://creativecommons.org/licenses/by/3.0/Amino/nitro substituted 3-arylcoumarinsPerkin reactionAntibacterial assaysS. aureusE. colijournal article10.3390/molecules180213941420-3049open access