Moriczi, MelindaPujol Muncunill, GemmaMartín Masot, RafaelJiménez Treviño, SantiagoSegarra Cantón, OscarOchoa Sangrador, CarlosPeña Quintana, LuísGonzález Santana, DanielRodríguez Martínez, AlejandroRosell Camps, AntonioArmas, HonorioBarrio, JosefaGonzález de Caldas, RafaelRodríguez Salas, MónicaBalmaseda Serrano, ElenaDonat Aliaga, EsterBodas Pinedo, AndrésVaquero Sosa, EstherVecino López, RaquelSolar Boga, AlfonsoMoreno Álvarez, AnaSánchez Sánchez, CésarTolín Hernani, MarGutiérrez Junquera, CarolinaMartinón Torres, NazarethLeis Trabazo, María RosauraEizaguirre, Francisco JavierGarcía Peris, MónicaMedina Benítez, EnriqueFernández Cebrián, RafaelFernández Caamaño, BeatrizVegas Álvarez, Ana MaríaCrespo Valderrábano, LauraAlonso Vicente, CarmenRubio Santiago, JavierGalera Martínez, RafaelGarcía Romero, RuthRos Arnal, IgnacioFernández Cebrián, SantiagoLorenzo Garrido, HelenaViada Bris, Javier FranciscoVelasco Rodríguez-Belvís, MartaBartolomé Porro, Juan ManuelBlanco Rodríguez, MiriamBarros García, PatriciaBotija, GonzaloChicano Marín, Francisco JoséLa Orden Izquierdo, EnriqueCrehuá Gaudiza, ElenaNavas López, Víctor ManuelMartín de Carpi, Javier2020-12-012020-12-012020Moriczi, M.; Pujol-Muncunill, G.; Martín-Masot, R.; Jiménez Treviño, S.; Segarra Cantón, O.; Ochoa Sangrador, C.; Peña Quintana, L.; González Santana, D.; Rodríguez Martínez, A.; Rosell Camps, A.; Armas, H.; Barrio, J.; González de Caldas, R.; Rodríguez Salas, M.; Balmaseda Serrano, E.; Donat Aliaga, E.; Bodas Pinedo, A.; Vaquero Sosa, E.; Vecino López, R.; Solar Boga, A.; Moreno Álvarez, A.; Sánchez Sánchez, C.; Tolín Hernani, M.; Gutiérrez Junquera, C.; Martinón Torres, N.; Leis Trabazo, M.R.; Eizaguirre, F.J.; García Peris, M.; Medina Benítez, E.; Fernández Caamaño, B.; Vegas Álvarez, A.M.; Crespo Valderrábano, L.; Alonso Vicente, C.; Rubio Santiago, J.; Galera-Martínez, R.; García-Romero, R.; Ros Arnal, I.; Fernández Cebrián, S.; Lorenzo Garrido, H.; Viada Bris, J.F.; Velasco Rodríguez-Belvis, M.; Bartolomé Porro, J.M.; Blanco Rodríguez, M.; Barros García, P.; Botija, G.; Chicano Marín, F.J.; La Orden Izquierdo, E.; Crehuá-Gaudiza, E.; Navas-López, V.M.; Martín-de-Carpi, J. Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP. Nutrients 2020, 12, 1012http://hdl.handle.net/10347/23884Exclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn´s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014–2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 ± 2.5 years. The median EEN duration was 8 weeks (IQR 6.6–8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn’s Disease activity index [wPCDAI] < 12.5). Faecal calprotectin (FC) levels (μg/g) decreased significantly after EEN (830 [IQR 500–1800] to 256 [IQR 120–585] p < 0.0001). Patients with wPCDAI ≤ 57.5, FC < 500 μg/g, CRP >15 mg/L and ileal involvement tended to respond better to EEN. EEN administered for 6–8 weeks is effective for inducing clinical remission. Due to the high response rate in our series, EEN should be used as the first-line therapy in luminal paediatric Crohn’s disease regardless of the location of disease and disease activityeng© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Inflammatory bowel diseaseCrohn’s diseaseExclusive enteral nutritionCalprotectinChildrenPaediatricjournal article10.3390/nu120410122072-6643open access