Rodríguez Villar, JéssicaMosquera Mosquera, JesúsVázquez Vázquez, OlallaVázquez Sentís, Marco EugenioMascareñas Cid, José Luis2019-03-272019-03-272014Rodríguez, J., Mosquera, J., Vázquez, O., Vázquez, M., & Mascareñas, J. (2014). The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative. Chem. Commun.,50, 2258-2260. doi: 10.1039/c3cc47599a1359-7345http://hdl.handle.net/10347/18487We report the selective modification of cysteine residues engineered in peptides that have two additional cysteine residues as part of a Cys2His2 zinc finger motif. The chemoselective modification is achieved, thanks to the protecting effect exerted by the zinc cation upon coordination with the native cysteines and histidines of the zinc-finger fold. The strategy allows a straightforward synthesis of DNA binding zinc finger constructseng© The Royal Society of Chemistry 2014journal article10.1039/C3CC47599A1364-548Xopen access