Rodríguez-Moldes Rey, María IsabelCandal Suárez, Eva MaríaSantos Durán, Gabriel NicolásUniversidade de Santiago de Compostela. Facultade de Bioloxía. Departamento de Bioloxía Celular e Ecoloxía2016-03-082016-03-082016-03-08http://hdl.handle.net/10347/13930The hypothalamus is a conserved integrative center with a complex organization result of a complex patterning processes. Here we make use of a evo-devo approach and the theoretical framework of the prosomeric model to understand the organization of the vertebrate hypothalamus. We studied the gene expression patterns of ScFoxg1a, ScDlx2/5, ScOtp, ScShh, ScNkx2.1, ScTbr1, ScNeurog2, ScLhx5, ScLhx9, ScDlx2/5, ScNkx2.8, ScEmx2, ScLmx1b, ScPitx2, ScPitx3a, ScNeurog2, ScFoxa1 and ScFoxa2 besides immunoreactivity to Pax6, PCNA and other immunomarkers in the embryonic hypothalamus and neighbour prosencephalic territories of a cartilaginous fish, the catshark, Scyliorhinus canicula. Our comparative analysis reveals the existence of conserved traits but also suggests an alternative organization to that proposed by the prosomeric model for the hypothalamus and even for the anterior prosencephalon of vertebrates.engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhypothalamusChondrichthyansevo-devoprosomeric modelprosencephalonMaterias::Investigación::24 Ciencias de la vida::2490 Neurociencias::249002 NeuroquímicaMaterias::Investigación::24 Ciencias de la vida::2407 Biología celular::240702 CitogenéticaMaterias::Investigación::24 Ciencias de la vida::2401 Biología animal (zoología)::240107 Embriología animaldoctoral thesisopen access