Antelo Queijo, ÁlvaroÁlvarez Alcalde, María de las MercedesJover Ramos, AidaMeijide del Río, Francisco ÁngelGalantini, LucianoVázquez Tato, José2021-08-192021-08-192009Vázquez Tato, J.; Galantini, L.; Meijide, F.; Jover, A.; Alvarez Alcalde, M.; Antelo, A. Complexation of 3α,7α,12α-trihydroxy-5β-cholan-24-amine by β- and γ-cyclodextrins, in Proceedings of the 13th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2009, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-13-002593-906980-23-5http://hdl.handle.net/10347/26863The 13th International Electronic Conference on Synthetic Organic Chemistry session Polymer and Supramolecular ChemistryThe binding constants, standard molar enthalpy, Gibbs free energy, and entropy changes were determined for the formation of inclusion complexes between 3α,7α,12α- trihydroxy-5β-cholan-24-amine, C24NH2, and β-cyclodextrin and γ-cyclodextrin. The stoichiometry of both complexes is 1:1 in agreement with previously reported results for other trihydroxy bile salts. The equilibrium constant values for the formation of the inclusion complex are similar as well. The structure of the C24NH2/γ-cyclodextrin complex was studied by ROESY experiments. These results suggest that B, C and Drings of the steroid skeleton, as well as the side chain, interact with the cyclodextrin cavity, while the A ring of the steroid nucleus remains outside the cavityeng© 2009 The author(s). Published by MDPI, Basel, Switzerland. Open Accessbook part10.3390/ecsoc-13-00259open access