Nelson, RonaldGulías Costa, MoisésMascareñas Cid, José LuisLópez García, Fernando2016-12-142017-10-132016-10-13R. Nelson, M. Gulías, J. L. Mascareñas, F. López, Angew. Chem. Int. Ed. 2016, 55, 14359http://hdl.handle.net/10347/15018NOTICE: This is the peer reviewed version of the following article: Ronald Nelson, Moisés Gulías, José L. Mascareñas*, Fernando López* (2016), A Concise, Enantioselective and Versatile Synthesis of (-)-Englerin A based on a Pt-catalyzed [4C+3C] Cycloaddition of Allenedienes, Angew. Chem. Int. Ed., 55, 1-6 [doi:10.1002/anie.201607348]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archivingA practical synthesis of (−)-englerin A was accomplished in 17 steps and 11 % global yield from commercially available achiral precursors. The key step consists of a platinum-catalyzed [4C+3C] allenediene cycloaddition that directly delivers the trans-fused guaiane skeleton with complete diastereoselectivity. The high enantioselectivity (99 % ee) stems from an asymmetric ruthenium-catalyzed transfer hydrogenation of a readily assembled diene–ynone. The synthesis also features a highly stereoselective oxygenation, and a late-stage cuprate alkylation that enables the preparation of previously inaccessible structural analogueseng© WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimEnglerin-AAchiral precursorsCycloadditionAllenesAsymmetric catalysisGuaiane natural productsTotal synthesisMaterias::Investigación::23 Químicajournal article10.1002/anie.2016073481521-3773open access