Rodríguez Villar, JéssicaPérez González, CibránMartínez-Calvo, MiguelMosquera Mosquera, JesúsMascareñas Cid, José Luis2022-01-272022-01-272022RSC Adv., 2022, 12, 3500http://hdl.handle.net/10347/27429Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions of bZIP transcription factors. While the dimer binds designed DNA sequences with good affinities, the peptide–DNA complex can be readily dismounted by addition of palladium reagents that trigger the cleavage of the spacer, and the release of unfunctional monomeric peptideseng© 2022 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/)Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/journal article10.1039/d1ra09180h2046-2069open access