Pituco, Mateus MestrinerMarrocos, Paulo H.Méndez, SandraMontes Goyanes, RosaRodil Rodríguez, María del RosarioMoreira, Francisca C.Vilar, Vítor J. P.2025-09-252025-09-252025-04Journal of Environmental Chemical Engineering Volume 13, Issue 2, April 2025, 115465https://hdl.handle.net/10347/42899An innovative high-intensity static mixer technology, known as NETmix, was applied as an ozone (O3) gas injection system to promote the quaternary treatment of urban wastewater (UWW), focusing on the elimination of contaminants of emerging concern (CECs). The NETmix network with an exclusive geometry boosts mass transfer rates and rapidly develops an O3-rich stream to react with CECs. The mixer operated in continuous mode promotes a rapid gas (O3)–liquid (water) dissolution. The ozonation process’ performance was evaluated for the abatement of 19 CECs spiked (10 μg dm−3 each) in demineralized water and two tertiary-treated UWW matrices, coming from (i) a secondary settler tank after a conventional activated sludge and (ii) the outlet of a membrane biological reactor (MBR). In addition, the ozonation system was tested for removing a broad range of CECs at natural trace levels from the UWW matrix coming from the MBR. In the realistic wastewater contamination scenario, a maximum transferred O3 dose of 1.28 and 0.76 resulted in removal values ≥80% for 12 out of the 19 spiked CECs from the secondary settler tank, and 9 out of the 19 spiked CECs from the post-MBR treatment, respectively, at a very short hydraulic residence time (55 s). Moreover, removals ≥80% were attained for 22 out of 25 CECs detected in the effluent from the MBR, applying a specific O3 dose of 0.6 . The enhanced ozone-water mass transfer provided by the NETmix technology enabled high removal efficiencies for CECs.eng© 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license. Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/OzonationContaminants of emerging concernStatic mixerGas-liquid mass transferOzone absorption ratejournal article10.1016/j.jece.2025.1154652213-3437open access