González Bello, Concepción2017-11-082017-11-082017-08-140960-894Xhttp://hdl.handle.net/10347/16122Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the number of strains that are resistant to multiple types of antibiotics has increased dramatically each year and has spread worldwide. To unlock this problem, the use of an ‘antibiotic adjuvant’ in combination with an antibiotic is now being exploited. This approach enables us to prolong the lifespan of these life-saving drugs. This digests review provides an overview of the main types of antibiotic adjuvants, the basis of their operation and the remaining issues to be tackled in this field. Particular emphasis is placed on those compounds that are already in clinical development, namely b-lactamase inhibitorseng(c) 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)http://creativecommons.org/licenses/by-nc-nd/4.0/Resistance breakersAntibiotic potentiatorsESKAPE pathogensb-Lactamase inhibitorsEfflux pump inhibitorsPermeabilizersMaterias::Investigación::23 Química::2390 Química farmacéuticajournal article10.1016/j.bmcl.2017.08.027open access