Rodríguez Villar, JéssicaMosquera Mosquera, JesúsRodríguez Couceiro, JoséVázquez Sentís, Marco EugenioMascareñas Cid, José Luis2019-03-122019-03-122015Rodríguez, J., Mosquera, J., Couceiro, J., Vázquez, M., & Mascareñas, J. (2015). The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments. Chemical Science, 6(8), 4767-4771. doi: 10.1039/c5sc01415hhttp://hdl.handle.net/10347/18337We report the development of chimeric DNA binding peptides comprising a DNA binding fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric zinc finger module) and an AT-Hook peptide motif. The resulting peptide conjugates display high DNA affinity and excellent sequence selectivity. Furthermore, the AT-Hook motif also favors the cell internalization of the conjugateseng© The Royal Society of Chemistry 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedhttps://creativecommons.org/licenses/by/3.0/journal article10.1039/c5sc01415h2041-6539open access