Barreiro Magdaleno, ElenaCasas Fernández, José SergioCouce, María D.Sánchez Díaz, AgustínSeoane Prado, RafaelPérez Estévez, AntonioSordo Rodríguez, José2021-01-272021-01-272012Barreiro, E., Casas, J.S., Couce, M.D. et al. Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates. Gold Bull 45, 23–34 (2012). https://doi.org/10.1007/s13404-011-0040-72364-821Xhttp://hdl.handle.net/10347/24338Reaction of NaAuCl4·H2O and thiodiglycol (1:3 molar ratio) with 3-(aryl)-2-sulfanylpropenoic acids, H2 xspa = [x:p = 3-phenyl-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-, o-py = 3-(2-pyridyl)-, Clp = 3-(2-chlorophenyl)-, -o-mp = 3-(2-methoxyphenyl)-, -p-mp = 3-(4-methoxyphenyl)-, -o-hp = 3-(2-hydroxyphenyl)-, -p-hp = 3-(4-hydroxyphenyl)-, diBr-o-hp = 3-(3,5-dibromo-2-hydroxyphenyl)] and 2-cyclopentylidene-2-sulfanylacetic acid (H2cpa) in a 1:1 metal/ligand molar ratio gave compounds of the type [Au(Hxspa)] or [Au(Hcpa)]. These compounds were reacted with diisopropylamine to afford [HQ][Au(xspa)] or [HQ][Au(cpa)] (HQ = diisopropylammonium) and with NaOH to afford Na[Au(xspa)]·H2O and Na[Au(cpa)]·H2O. All of the new compounds were isolated and characterised by IR and 1H and 13C NMR spectroscopy. The antimicrobial activities of the complexes against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Pseudomonas aeruginosa and carbapenem-resistant P. aeruginosa were evaluated and compared to those of the equivalent silver(I) complexes. The comparison shows that the gold compounds generally show better activity than the silver analogues against S. aureus and B. subtilis, but low sensitivity against E. coli, P. aeruginosa and C. albicans, suggesting a different mode of antimicrobial action for equivalent silver and gold compoundseng© The Author(s) 2012. Open Access. This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are creditedhttps://creativecommons.org/licenses/by-nc/2.0Gold(I) complexesSulfanylpropenoic acids2-Cyclopentylidene-2-sulfanylacetic acidAntimicrobial studiesjournal article10.1007/s13404-011-0040-72190-7579open access