Losada Castro, PabloMascareñas Cid, José LuisGulías Costa, Moisés2026-05-182026-05-182026-04-06Losada, P., Mascareñas, J. L., & Gulías, M. (2026). Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C-H Alkenylation. "Organic letters", 28(15), 4836-4840. https://doi.org/10.1021/ACS.ORGLETT.6C009114836–4840https://hdl.handle.net/10347/47246A concise, nine-step total synthesis of isoriccardin C and isoriccardin D has been developed. The strategy centers on the sequential installation of the four aromatic rings of the backbone by using three key transformations: Suzuki coupling, Wittig olefination, and Ullmann coupling. The pivotal step is a palladium(II)-catalyzed, intramolecular ortho-alkenylation that forges the 18-membered macrocyclic core. This streamlined route enables the total synthesis with minimal reliance on protecting groups, and its modular nature offers a versatile platform for the construction of structural analogues.engCopyright © 2026 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0 .Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Chemical synthesisHydrocarbonsMacrocyclizationOlefinationOrganic synthesis2306 Química orgánica2390 Química farmacéutica2210 Química física3303 ingeniería y tecnología químicasjournal article10.1021/acs.orglett.6c00911open access