Díaz Arias, Sandra NataliaSánchez Fernández, AdriánGranja Guillán, Juan RamónInsua López, IgnacioMontenegro García, Javier2026-04-202026-04-202026-02-26Díaz, S., Sanchez-Fernandez, A., Granja, J. R., Insua, I., & Montenegro, J. (2026). 3D self-assembly of cyclic peptides into multilayered nanosheets. Chemical Science, 17(13), 6727-6733. https://doi.org/10.1039/d5sc09489e2041-6520https://hdl.handle.net/10347/46806The hierarchical self-assembly of three-dimensional (3D) supramolecular materials presents a significant challenge in molecular design. This process requires monomers with specific packing geometries and orthogonal contacts to enable multidimensional elongation. Here, we describe a new cyclic peptide design that allows hierarchical self-assembly in all three spatial dimensions to produce nanosheets composed of ordered nanotube layers. The uniformity of the nanosheet aspect ratio and thickness is consistent with the high packing order of the monomers observed in this 3D assembly.engThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.3303 ingeniería y tecnología químicasjournal article10.1039/D5SC09489E2041-6539open access