García Queiruga, JacoboPena Verdeal, HugoFerreiro Figueiras, Dolores PurificaciónGarcía Resúa, CarlosYebra-Pimentel Vilar, Eva2024-02-122024-02-122019Jacobo Garcia-Queiruga, Hugo Pena-Verdeal, Dolores Ferreiro, Carlos García-Resua, and Eva Yebra-Pimentel "Meibomian gland loss area and its relationship with age and ocular surface disease index", Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, 112071B (3 October 2019)http://hdl.handle.net/10347/32805Purpose: Meibography images bring information about the status and integrity of the meibomian glands (MG). This study aimed to correlate the meibomian gland loss area (MGLA) with age and dry eye symptomatology. Material and methods: A total of 110 subjects were recruited for the study. From the Meibography images obtained with the Topcon® CA-800 topographer, MGLA was calculated as the difference between the total area of the tarsus and the MG presence area measured by using the ImageJ software. Before the examination, all subjects completed an OSDI questionnaire. OSDI scores were grouped in 4 severity categories: normal (score ≤12), mild (score 12–22), moderate (score 22–32) and severe (score ≥32). Age was categorised into 3 subgroups: ≤25 years, from 25 to 45 years and ≥45 years. MGLA was also grouped in 4 categories of loss: ≤25 %, from 25 to 50%, from 50 to 75% and ≥75%. Results: Analysis was performed by dividing the sample into the 4 MGLA subgroups; these subgroups showed age differences (p=0.029; Kruskal-Wallis test) and differences in OSDI scores (p=0.001; Kruskal-Wallis test). The sample was divided into 3 age subgroups and differences were obtained in MGLA values among subgroups (p<0.001; Kruskal-Wallis test). Samples were divided in 4 OSDI subgroups and differences were obtained in MGLA values among subgroups (p=0.003; Kruskal-Wallis test). Positive correlation (Spearman Correlation) was obtained for both, MGLA vs. age (r=0.329, p<0.001) and MGLA vs. OSDI (r=0.380, p<0.001). Conclusion: In the present study MGLA showed a relationship with age and OSDI.eng© 2019 SPIEMeibomian GlandsTopcon CA-800 topographerMeibomian gland loss areMGDDry eye symptomatologyImageJjournal article10.1117/12.2527349open access