Alonso Fernández, María JoséTorres López, DoloresOlivera Fernández, Ana2021-01-282021-01-282020http://hdl.handle.net/10347/24343Nanotechnology offers the possibility of enhancing the performance of immunomodulatory molecules by facilitating their transport across biological barriers and targeting them to the immune system. Considering this promising potential, this thesis has focused on the development of polymeric nanocarriers loaded with an immunomodulatory molecule for the prevention of type 1 diabetes. Furthermore, pursuing the transdermal supplementation of this molecule, these nanocarriers were optimized to enhance its penetration across the skin.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/nanotechnologyimmunomodulationsupplementationautoimmunitytoleranceMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentosMaterias::Investigación::32 Ciencias médicas::3207 Patología::320710 InmunopatologíaMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320903 Evaluación de medicamentosdoctoral thesisopen access