Hermida Nogueira, LidiaGarcía Alonso, Ángel2021-07-282021-07-282021Hermida-Nogueira, L, García, Á. Viewpoint: Extracellular vesicles in the transfusion medicine field: The potential of proteomics. Proteomics. 2021; 21:e2000089. https://doi.org/10.1002/pmic.202000089http://hdl.handle.net/10347/26625In transfusion centres, blood components are divided and stored following specific guidelines. The storage temperature and time vary among the blood cells but all of them release extracellular vesicles (EVs) under blood bank conditions. The clinical impact of such vesicles in blood components for transfusion is an object of debate, but should be considered and is being investigated. In this context, proteomics is an excellent tool to study the cargo and composition of EVs derived from red blood cells and platelets, since such vesicles are enriched in lipids and proteins. The development of quantitative mass spectrometry techniques and the evolution of bioinformatics have allowed the identification of novel EVs biomarkers for different diseases. In this context, the application of high coverage proteomic tools to the analysis of EVs in the transfusion medicine field would provide information about storage lesions and possible transfusion adverse reactions. This viewpoint article approaches the potential of proteomics to investigate the impact of EVs in blood bank transfusion components, especially red blood cells and plateletseng© 2021 The Authors. Proteomics published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly citedAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Extracellular vesiclesProteomicsTransfusion medicinejournal article10.1002/pmic.2020000891615-9861open access