Landín Pérez, MarianaRemuñán López, CarmenRouco Taboada, Helena2021-04-262022-03-112021http://hdl.handle.net/10347/26059In this work, we rationally developed a lipid-based nanotechnological platform for hydrophobic anti-mycobacterial drugs. For this purpose, Artificial Intelligence tools were employed to assist formulation development, from the initial design to its conversion into a solid dosage form. Reproducible nanocarriers exhibiting suitable properties were achieved through a simple and robust procedure. Furthermore, the analysis of their in vitro performance revealed promising results in terms of permeability, cell uptake and selective intracellular release. Thus demonstrating the potential of these nanosystems to treat intestinal intracellular infections, increasingly related with Crohn´s disease development.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Lipid nanoparticlesQuality-by-designArtificial IntelligenceAntibioticsMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320902 Composición de medicamentosMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentosMaterias::Investigación::12 Matemáticas::1203 Ciencia de los ordenadores::120304 Inteligencia artificialdoctoral thesisopen access