Barca Mayo, OlgaPons-Espinal, MeritxellFollert, PhilippArmirotti, AndreaBerdondini, LucaDe Pietri Tonelli, Davide2025-01-162025-01-162017-02-10Barca-Mayo, O., Pons-Espinal, M., Follert, P., Armirotti, A., Berdondini, L., De Pietri Tonelli, D. (2017). Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signaling. “Nature Communications”, vol. 8, 14336.2041-1723https://hdl.handle.net/10347/38624Descrición física: El documento consta de 14 páxinas numeradas electrónicamente (14336) e inclúe gráficos, ilustracións e táboas. Información adicional sobre a/s Persoa/s autora/s: Este traballo foi realizado por Olga Barca-Mayo e colaboradores, pertencendo á súa liña de investigación sobre ritmos circadianos e astrocitos. Presentación do traballo: Resultados deste artigo foron presentados en múltiples congresos internacionais, incluíndo a Gordon Research Conference en Gerona, España (2015), e o encontro anual da Japan Neuroscience Society en Kobe, Xapón (2015). Fórmula sobre copyright: Este artigo foi publicado baixo a licenza Creative Commons Attribution 4.0 (CC BY 4.0), que permite o uso, distribución e reprodución en calquera medio, sempre que se acredite ao autor orixinal e á fonte. A versión definitiva está dispoñible en: https://doi.org/10.1038/ncomms14336.Circadian rhythms are controlled by a network of clock neurons in the central pacemaker, the suprachiasmatic nucleus (SCN). Core clock genes, such as Bmal1, are expressed in SCN neurons and in other brain cells, such as astrocytes. However, the role of astrocytic clock genes in controlling rhythmic behaviour is unknown. Here we show that ablation of Bmal1 in GLAST-positive astrocytes alters circadian locomotor behaviour and cognition in mice. Specifically, deletion of astrocytic Bmal1 has an impact on the neuronal clock through GABA signalling. Importantly, pharmacological modulation of GABAA-receptor signalling completely rescues the behavioural phenotypes. Our results reveal a crucial role of astrocytic Bmal1 for the coordination of neuronal clocks and propose a new cellular target, astrocytes, for neuropharmacology of transient or chronic perturbation of circadian rhythms, where alteration of astrocytic clock genes might contribute to the impairment of the neurobehavioural outputs such as cognition.eng© 2017 The Authors. Nature Communications published by Springer Nature. This is an open access article under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. The definitive version is available online at: https://doi.org/10.1038/ncomms14336.http://creativecommons.org/licenses/by/4.0/Ritmos circadianosAstrocitosComportamientoMemoriaGABA249001 Neurofisiología240701 Cultivo celular241111 Neurofisiologíajournal article10.1038/ncomms14336open access