Bugallo Carrera, CésarFacal Mayo, DavidDomínguez Lenogue, CristinaÁlvarez Vidal, VanessaGandoy Crego, ManuelCaamaño Ponte, José Luis2023-06-302023-06-302022Bugallo-Carrera, C.; Facal, D.; Domínguez-Lenogue, C.; Álvarez-Vidal, V.; Gandoy-Crego, M.; Caamaño-Ponte, J. Neuropsychiatric symptoms after liver transplantation in a 65-year-old male patient. Brain Sci. 2022, 12, 1721http://hdl.handle.net/10347/30815The development of immunosuppressants has been key for the advancement of solid organ transplant surgery. Specifically, cyclosporine, tacrolimus, or everolimus have significantly increased the survival rate of patients by reducing the risk of a rejection of the transplanted organ and limiting graft-versus-host disease. We report the case of a 65-year-old man who, after undergoing a liver transplantation and receiving an immunosuppressive treatment with cyclosporine and everolimus, presented severe obsessive, psychotic, and behavioral symptoms over the past three years, and describe the pharmacological and non-pharmacological interventions implemented against these symptoms. In this case, the immunosuppressants used have been cyclosporine and, preferably, everolimus. On the other hand, potential adverse reactions to the treatment have been observed, including neuropsychiatric symptoms such as tremor, anxiety, dysthymia, psychosis, and behavioral disorders, which make it necessary to use corrective psychoactive drugs such as benzodiazepines, antidepressants, and antipsychotics, combined with non-pharmacological interventions. A transversal approach, from the medical and psychosocial disciplines, facilitates success in managing neuropsychiatric symptoms after soft organ transplantseng© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)Liver transplantImmunosuppressionNeurotoxicityPsychosisDepressionAnxietyCognitive interventionjournal article10.3390/brainsci121217212076-3425open access