Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C

Gulías Costa, MoisésMarcos-Atanes, DanielMascareñas Cid, José LuisFont Molíns, Marc2020-02-202020-07-152019Org. Process Res. Dev. 2019, 23, 8, 1669-16731083-6160http://hdl.handle.net/10347/20793This document is the Accepted Manuscript version of a Published Work that appeared in final form in Org. Process Res. Dev., copyright © 2019 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://doi.org/10.1021/acs.oprd.9b00191Herein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and coumarins can be scaled up to 33 mmol using low catalyst loadingseng© 2019 American Chemical SocietyMultigram-scale synthesisBenzoxepinesCoumarinsPractical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactionsjournal article10.1021/acs.oprd.9b001911520-586Xopen access