Seoane Fernández, AndrésCasanova González, NoeliaQuiñones, NoeliaMascareñas Cid, José LuisGulías Costa, Moisés2019-03-272019-03-272014Seoane, A., Casanova, N., Quiñones, N., Mascareñas, J., & Gulías, M. (2014). Straightforward Assembly of Benzoxepines by Means of a Rhodium(III)-Catalyzed C–H Functionalization of o-Vinylphenols. J. Am. Chem. Soc., 136, 3, 834-837. DOI: 10.1021/ja410538w0002-7863http://hdl.handle.net/10347/18478This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/doi/10.1021/ja410538wReadily available o-vinylphenols undergo a formal (5 + 2) cycloaddition to alkynes when treated with catalytic amounts of [Cp*RhCl2]2 and Cu(OAc)2. The reaction, which involves the cleavage of the terminal C–H bond of the alkenyl moiety, generates highly valuable benzoxepine skeletons in a practical, versatile, and atom-economical manner. Using carbon monoxide instead of an alkyne as reaction partner leads to coumarin products which formally result from a (5 + 1) cycloadditioneng© 2014 American Chemical Societyjournal article10.1021/ja410538w1520-5126open access