García Queiruga, JacoboPena Verdeal, HugoSabucedo Villamarín, BelénGarcía Resúa, CarlosGiráldez Fernández, María JesúsYebra-Pimentel Vilar, Eva2024-01-312024-01-312023-05-19Jacobo Garcia-Queiruga , Hugo Pena-Verdeal , Belén Sabucedo-Villamarin , Carlos Garcia-Resua , Maria J. Giraldez & Eva Yebra-Pimentel (2023) Analysis of the Differences in Ocular Surface Damage and Inflammatory Signs between Healthy and Evaporative Dry Eye Participants, Ocular Immunology and Inflammation, 31:5, 970-977, DOI: 10.1080/09273948.2022.20753980927-3948http://hdl.handle.net/10347/32142This is an Accepted Manuscript of an article published by Taylor & Francis in "Ocular Immunology and Inflammation" on 2022/05/19, available at: https://doi.org/10.1080/09273948.2022.2075398Objective: Distinguish between EDE severity levels by analysing the MGLA, conjunctival hyperemia and corneal staining. Methods: One hundred participants were recruited based on OSDI, TO, TFBUT, TMH, and LLP to be categorised as healthy (Group 1) or EDE (Group 2). Group 2 was divided into Group 2A (mild symptoms), 2B (moderate), and 2C (severe). MGLA, conjunctival hyperemia, and corneal staining were measured. Results: Positive correlation between MGLA, conjunctival hyperemia, and corneal staining were found (all r ≥ 0.221, p ≤ 0.027). Significant differences were found: MGLA between Group 1 vs. 2C and 2C vs. 2A or 2B; conjunctival hyperemia between Group 1 vs. 2A, 2B or 2C; corneal staining between Group 1 vs. 2B or 2C and 2A vs. 2B or 2C (all p ≤ 0.049). Conclusion: Severe EDE participants have higher MGLA, conjunctival hyperemia, and corneal staining values than healthy, mild, or moderate EDE participants.eng© Taylor and Francishttps://creativecommons.org/licenses/by-nc/4.0/deed.esConjunctival hyperemiaCorneal stainingEvaporative dry eyeMeibographyMeibomian gland loss areajournal article10.1080/09273948.2022.20753981744-5078open access