Alonso Fernández, María JoséCrecente Campo, JoséBerrecoso Cuña, Germán2023-03-152023http://hdl.handle.net/10347/30311The main objectives of this thesis were, first, to characterize the chemical, physicochemical, and biological composition following the Minimum Information about Nanomaterial Biocorona Experiments (MINBE) recommendations of blank polymeric NCs, second, to develop NCs loaded with chemotherapeutics and immunomodulators (STAT3 and TGF-β pathway inhibitors), and third, to develop a nanotechnology platform for the intracellular delivery of mAb (bevacizumab as a model mAb, and anti-KRASG12V mAb as therapeutic mAb).engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Nanotechnologynanocapsulesprotein coronaimmunomodulatorsmonoclonal antibodieslung cancerNSCLCMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentosMaterias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320802 Acción de los medicamentosdoctoral thesisopen access