Gutiérrez González, AlejandroLópez García, Fernando JoséMascareñas Cid, José Luis2023-06-152023-06-152023Gutiérrez-González, A., López, F., Mascareñas, J. L., Helv. Chim. Acta 2023, 106, e2023000010018-019Xhttp://hdl.handle.net/10347/30679Dedicated to Prof. Janine CossyRecent years have witnessed a considerable progress in research aimed at merging transition metal catalysis with chemical and cell biology. Therefore, a crescent number of metal-catalyzed transformations have been shown compatible with biological media and even with living settings. Of the different transition metals used to build these biocompatible catalysts, ruthenium has demonstrated to be particularly powerful, in part because the resulting complexes exhibit a very good balance between reactivity and biological stability. Indeed, ruthenium complexes have demonstrated utility to promote a great variety of reactions in biologically relevant contexts, from deprotection and redox processes to cycloadditions or photocatalytic transformations. Many of these reactions may enable the development of new type of biological tools and pharmacological strategieseng© 2023 The Authors. Helvetica Chimica Acta published by Wiley-VHCA AG, Zurich, Switzerland This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/BioconjugationBioorthogonal chemistryFluorescenceOrganometallic chemistryTransition metalsjournal article10.1002/hlca.2023000011522-2675open access