Mateos, JaimeRivera Chao, EvaFañanás-Mastral, Martín2018-07-132018-07-132017-07-12Jaime Mateos, Eva Rivera-Chao, and Martín Fañanás-Mastral ACS Catalysis 2017 7 (8), 5340-5344 DOI: 10.1021/acscatal.7b018332155-5435http://hdl.handle.net/10347/17015A Cu/Pd-catalyzed allylboration of alkynes with allyl carbonates and bis(pinacolato)diboron to afford borylated skipped dienes is reported. Synergistic Cu and Pd catalysis enables this protocol to work for a wide array of alkynes and allyl carbonates under mild conditions with total regio- and stereocontrol. This transformation features the catalytic generation of β-borylalkenylcopper intermediates and their use in Pd-catalyzed allylic substitution of allyl carbonates. The utility of this method is highlighted by the synthesis of (Z,E)-α-homofarnesene (pheromone) and the terpenoid precursor of Merochlorins (potent antibiotic agents)eng© 2017 American Chemical SocietyCopperMulticomponent reactionsPalladiumSkipped dienesSynergistic catalysisjournal article10.1021/acscatal.7b01833open access