Sotelo Pérez, EddyMallo Abreu, Ana2021-10-132021-10-132021http://hdl.handle.net/10347/26989This PhD thesis describes the synthesis and optimization of novel families of potent and selective A2B antagonists and D2 biased partial agonists, thus contributing to the discovery of therapeutic agents for the treatment of pathologies such as cancer, schizophrenia, or Parkinson's disease. The chemical entities obtained were conceived using different design criteria and assembled using convergent, highly exploratory, and experimentally simple multicomponent reactions. The pharmacological characterization of the obtained libraries enabled the identification of A2BAR antagonists eliciting excellent potency, selectivity, and metabolic stability; as well as the identification of previously unexplored DRD2 biased partial agonists.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Multicomponent reactionsDopamine D2 receptorsAdenosine A2B antagonistsHit identification in drug discovery Biased ligandsMaterias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320804 Lugar de acción activa, receptoresMaterias::Investigación::23 Química::2390 Química farmacéutica::239001 Diseño. Síntesis y estudio nuevos fármacosMaterias::Investigación::23 Química::2306 Química orgánica::230607 Química del carboniodoctoral thesisopen access