Rodríguez Villar, JéssicaMosquera Mosquera, JesúsRodríguez Couceiro, JoséVázquez Sentís, Marco EugenioMascareñas Cid, José Luis2019-03-122019-03-122016J. Rodríguez, J. Mosquera, J. R. Couceiro, M. E. Vázquez, J. L. Mascareñas, Angew. Chem. Int. Ed. 2016, 55, 156151433-7851http://hdl.handle.net/10347/18334Guanine quadruplexes (GQs) are compact four‐stranded DNA structures that play a key role in the control of a variety of biological processes, including gene transcription. Bulky ruthenium complexes featuring a bipyridine, a terpyridine, and one exchangeable ligand ([Ru(terpy)(bpy)X]n+) are able to metalate exposed guanines present in the GQ of the c‐MYC promoter region that are not involved in quadruplex base pairing. qRT‐PCR and western‐blot experiments indicated that the complexes promote a remarkable increase in the expression of this oncogene. We also show that exchangeable thioether ligands (X=RSR′, Met) allow regulation of the metalating activity of the complex with visible lighteng© 2016 Die Autoren. Verçffentlicht von Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This article is licensed under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)http://creativecommons.org/licenses/by-nc-nd/4.0/Bioinorganic chemistryDNA damageMetalationPhotochemistryRutheniumjournal article10.1002/anie.2016079651521-3773open access