Sánchez Díaz-Marta, AntonioTubío, Carmen R.Carbajales Pérez, CarlosFernández, CarmenEscalante Escalante, Luz ElizabethSotelo Pérez, EddyGuitián Rivera, FranciscoBarrio, LauraGil González, ÁlvaroCoelho Cotón, Alberto José2024-02-072024-02-072017Díaz-Marta, A.S. Tubío, C.R., Carbajales, C., Fernandez, C., Escalante, L., Sotelo, E., Guitián, F., Barrio, V. L., Gil, A., Coelho, A. (2018). Three-Dimensional Printing in Catalysis: Combining 3D Heterogeneous Copper and Palladium Catalysts for Multicatalytic Multicomponent Reactions. "ACS Catalysis". Vol. 8, 392-404http://hdl.handle.net/10347/32506This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Catalysis, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acscatal.7b02592Two 3D-hybrid monolithic catalysts containing immobilized copper and palladium species on a silica support were synthesized by 3D printing and a subsequent surface functionalization protocol. The resulting 3D monoliths provided a structure with pore sizes around 300 μm, high mechanical strength, and easy catalyst recyclability. The devices were designed to perform heterogeneous multicatalytic multicomponent reactions (MMCRs) based on a copper alkyne–azide cycloaddition (CuAAC) + palladium catalyzed cross-coupling (PCCC) strategy, which allowed the rapid assembly of variously substituted 1,2,3-triazoles using a mixture of tBuOH/H2O as solvent. The reusable multicatalytic system developed in this work is an example of a practical miniaturized and compartmental heterogeneous 3D-printed metal catalyst to perform MMCRs for solution chemistry.engCopyright © American Chemical Societyhttp://creativecommons.org/licenses/by-nc-nd/4.0/3D-printingHeterogeneous catalystsCuAACPalladiumMulticatalytic multicomponent reactions230613 Química de los organosilícicos2306 Química orgánicajournal article10.1021/acscatal.7b025922155-5435open access