Paz Castañal, Manuel María2021-08-192021-08-192010Proceedings of the 14th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2010, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-14-004823-906980-24-3http://hdl.handle.net/10347/26882The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products ChemistryWe report that the clinically used antitumor drug mitomycin C is reductively activated in vitro by simple thiols; a mechanism for this activation is proposed based on kinetic data and the identification of mitosene metabolites. The biological implications of these findings are discussedeng© 2010 The author(s). Published by MDPI, Basel, Switzerland. Open Accessbook part10.3390/ecsoc-14-00482open access