Vidal Vides, CristianTomás Gamasa, MaríaGutiérrez González, AlejandroMascareñas Cid, José Luis2019-05-022019-05-022019Vidal, C., Tomás-Gamasa, M., Gutiérrez-González, A., & Mascareñas, J. (2019). Ruthenium-Catalyzed Redox Isomerizations inside Living Cells. J. Am. Chem. Soc., 2019, 141 (13), pp 5125–5129. doi: 10.1021/jacs.9b008370002-7863http://hdl.handle.net/10347/18732Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the “in cellulo” generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cellseng© 2019 American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposesAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article10.1021/jacs.9b008371520-5126open access