Anfray, ClémentFernández Varela, CarmenUmmarino, AldoMaeda, AkihiroSironi, MarinaGandoy, SaraBrea Floriani, José ManuelLoza García, María IsabelLeón, SergioCalvo, AlfonsoCorrea Chinea, Juan FranciscoFernández Megía, EduardoAlonso Fernández, María JoséAllavena, PaolaCrecente Campo, JoséTorres Andón, Fernando2025-10-212025-10-212024-01-08Anfray, C., Fernández Varela, C., Ummarino, A., Maeda, A., Sironi, M., Gandoy, S., Brea, J., Loza, M. I., León, S., Calvo, A., Correa, J., Fernandez-Megia, E., Alonso, M. J., Allavena, P., Crecente-Campo, J., Torres Andón, F. (2024). Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors. "Frontiers in Immunology", vol. 14https://hdl.handle.net/10347/43311In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able to reprogram TAMs towards M1-like antitumor effector cells. The objective of our work has been to develop and evaluate polymeric nanocapsules (NCs) loaded with poly(I:C)+R848, to improve drug stability and systemic toxicity, and evaluate their targeting and therapeutic activity towards TAMs in the TME of solid tumorsengAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Polymeric nanocapsulesPoly(I:C)Resiquimod (R848)Tumor-associated macrophages (TAMs)Toll-like receptor (TLR)Antitumoral immunotherapyImmunotoxicologyCancer2306 Química orgánicajournal article10.3389/fimmu.2023.13348001664-3224open access