Blanco Carrión, JuanGarcía Alonso, ÁngelHermida Nogueira, LidiaCastro, Ana B.2024-10-012024-10-012024Blanco J, García Alonso A, Hermida-Nogueira L, Castro A. How to explain the beneficial effects of leucocyte- and platelet-rich fibrin. Periodontology 2000. 2024; 00: 1-21. doi:10.1111/prd.125700906-6713http://hdl.handle.net/10347/34980The survival of an organism relies on its ability to repair the damage caused by trauma, toxic agents, and inflammation. This process involving cell proliferation and differentiation is driven by several growth factors and is critically dependent on the organization of the extracellular matrix. Since autologous platelet concentrates (APCs) are fibrin matrices in which cells, growth factors, and cytokines are trapped and delivered over time, they are able to influence that response at different levels. The present review thoroughly describes the molecular components present in one of these APCs, leukocyte- and platelet-rich fibrin (L-PRF), and summarizes the level of evidence regarding the influence of L-PRF on anti-inflammatory reactions, analgesia, hemostasis, antimicrobial capacity, and its biological mechanisms on bone/soft tissue regeneration.engAtribución 4.0 Internacional© 2024 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.http://creativecommons.org/licenses/by/4.0/AnalgesicAntibacterialAntimicrobialBone healingBone regenerationHemostaticLeukocyte- and platelet-rich fibrinPainSoft tissue regenerationWound healingjournal article10.1111/prd.125701600-0757open access