Priegue Caamaño, Juan ManuelLouzao Pernas, IriaGallego Gómez, IvánMontenegro García, JavierGranja Guillán, Juan Ramón2022-10-312022-12-202021Org. Chem. Front., 2022,9, 1226-1233 https://doi.org/10.1039/D1QO01349A2052-4110http://hdl.handle.net/10347/29370Self-assembling cyclic peptide nanotubes are supramolecular structures whose diameter and external surface properties are precisely controlled. In this communication we describe a general strategy to align different molecules on top of the nanotube surface by using cyclic peptides bearing chemoreversible reactive groups. D,L-α-Cyclic peptides endowed with a hydrazide moiety were condensed with a pyrenecarboxyaldehyde to facilitate the nanotube formation and deposition on flat unfunctionalized surfaces. The hydrazide moieties can be liberated without affecting the tubular structure and then used to align on top of the nanotube other molecules bearing aldehyde functions. Additionally, the attachment of specific ligands allowed the supramolecular alignment of corresponding receptors, such as mannosyl aldehyde and concavaline-A, driven by the nanotube structure through complemetary protein–ligand interactionseng© The Royal Society of Chemistry, 2021journal article10.1039/D1QO01349A2052-4129open access