Pazos Randulfe, YolandaDomínguez Muñoz, Juan EnriqueGallego Gómez, RosalíaEstévez Pérez, Lara Sofía2019-05-292019-05-292019http://hdl.handle.net/10347/18839Pancreatic cancer is one of the most aggressive neoplasms due to its rapid spread and late diagnosis. The objective of this thesis is to elucidate the obestatin/GPR39 potential as a therapeutic target in chronic pancreatitis and pancreatic cancer. The expression of GPR39 found in normal pancreas indicates a possible regulatory and regenerative role for the obestatin/GPR39 system in the human pancreas. Likewise, the expression found in premalignant lesions could involve this system in the pathogenesis and progression to pancreatic adenocarcinoma. In addition, this system favours proliferative, invasive and tumoral settlement processes in immortalized cancer cell lines. These facts prompted us to postulate the use of GPR39 as a marker of tumoral progression and its applicability to antagonize the fundamental mechanisms associated with the development of pancreatic cancer.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/ObestatinaGPR39Cancro pancreáticoMaterias::Investigación::24 Ciencias de la vida::2411 Fisiología humana::241104 Fisiología endocrinaMaterias::Investigación::32 Ciencias médicas::3207 Patología::320713 Oncologíadoctoral thesisopen access