Varela-López, BenxamínZurrón Ocio, MontserratLindín Novo, MónicaDíaz Fernández, FernandoGaldo Álvarez, Santiago2025-01-242025-01-242024-10-05Varela-López, B., Zurrón, M., Lindín, M. et al. Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes. GeroScience (2024). https://doi.org/10.1007/s11357-024-01369-92509-2723, 2509-2715https://hdl.handle.net/10347/38994Functional connectivity studies to detect neurophysiological correlates of amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer’s disease, have generated contradictory results in terms of compensation and deterioration, as most of the studies did not distinguish between the different aMCI subtypes: single-domain aMCI (sd-aMCI) and multiple-domain aMCI (md-aMCI). The present study aimed to characterize the neurophysiological correlates of aMCI subtypes by using resting-state functional magnetic resonance imaging. The study included sd-aMCI (n = 29), md-aMCI (n = 26), and control (n = 30) participants. The data were subjected to independent component analysis (ICA) to explore the default mode network (DMN) and the fronto-parietal control network (FPCN). Additionally, seed-based and moderation analyses were conducted to investigate the connectivity of the medial temporal lobe and functional networks. aMCI subtypes presented differences in functional connectivity relative to the control group: sd-aMCI participants displayed increased FPCN connectivity and reduced connectivity between the posterior parahippocampal gyrus (PHG) and medial structures; md-aMCI participants exhibited lower FPCN connectivity, higher anterior PHG connectivity with frontal structures and lower posterior PHG connectivity with central-parietal and temporo-occipital areas. Additionally, md-aMCI participants showed higher posterior PHG connectivity with structures of the DMN than both control and sd-aMCI participants, potentially indicating more severe cognitive deficits. The results showed gradual and qualitative neurofunctional differences between the aMCI subgroups, suggesting the existence of compensatory (sd-aMCI) and deterioration (mdaMCI) mechanisms in functional networks, mainly originated in the DMN. The findings support consideration of the subgroups as different stages of MCI within the Alzheimer disease continuum.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Resting-state functional magnetic resonance imagingAmnestic MCIAmnestic MCI subtypesDefault mode networkFronto-parietal control networkjournal article10.1007/s11357-024-01369-9open access