Santos Zas, IcíaCid Díaz, TaniaGonzález Sánchez, JessicaGurriarán Rodríguez, UxíaSeoane Mosteiro, CarlosPorteiro Couto, BegoñaNogueiras Pozo, RubénCasabiell Pintos, Jesús AntonioRelova Quinteiro, José LuisGallego Gómez, RosalíaMouly, VincentPazos Randulfe, YolandaPérez Camiña, Jesús2026-01-152026-01-152017-05-18Santos-Zas, I., Cid-Díaz, T., González-Sánchez, J. et al. Obestatin controls skeletal muscle fiber-type determination. Sci Rep 7, 2137 (2017). https://doi.org/10.1038/s41598-017-02337-42045-2322https://hdl.handle.net/10347/45195Obestatin/GPR39 signaling stimulates skeletal muscle growth and repair by inducing both G-protein-dependent and -independent mechanisms linking the activated GPR39 receptor with distinct sets of accessory and effector proteins. In this work, we describe a new level of activity where obestatin signaling plays a role in the formation, contractile properties and metabolic profile of skeletal muscle through determination of oxidative fiber type. Our data indicate that obestatin regulates Mef2 activity and PGC-1α expression. Both mechanisms result in a shift in muscle metabolism and function. The increase in Mef2 and PGC-1α signaling activates oxidative capacity, whereas Akt/mTOR signaling positively regulates myofiber growth. Taken together, these data indicate that the obestatin signaling acts on muscle fiber-type program in skeletal muscleeng© The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International LicenseAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Obestatin/GPR39Skeletal musclejournal article10.1038/s41598-017-02337-4open access