Vidal Pereira, XandroFont Molíns, MarcCendón Mariño, BorjaMascareñas Cid, José LuisGulías Costa, Moisés2021-12-132021-12-132021Vidal, X.; Font, M.; Cendón, B.; Mascareñas, J. L.; Gulías, M. (2021), (4 + 2) Cycloadditions via Pd C(sp3)–H activation. Trends Chem., 3(12): 1102-1103. doi: 10.1016/j.trechm.2021.08.0092589-7209http://hdl.handle.net/10347/27179The functionalization of aliphatic C (sp3)-H bonds using Pd catalysis has emerged as a powerful, step economical methodology for the construction of C–C and C–X bonds. Despite the progress in this field, examples of formal cycloadditions entailing this type of activation have been essentially limited to carbonylation processes. This work describes a formal (4 + 2) cycloaddition between alkylamides and dienes, a reaction that provides a direct, simple, and unconventional access to saturated lactamseng©2021, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (https://creativecommons.org/licenses/by-nc-nd/4.0/)Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article10.1016/j.trechm.2021.08.0092589-5974open access